Paul R. Cheney, PhD, MD
The Cheney Clinic
Cheney Seminar 2009 DVD sets available as of June 22, 2009!Page last updated June 25, 2009
The Cheney Clinic
About Paul R Cheney, MD, PhD
1 Vanderbilt Park Dr Ste 230
Cheney has been interested in many aspects of ME/CFS for more than 20
years. He was a founding Director of the American Association of CFS
(now the International Association for CFS/ME).
following a successful heart transplant in 2003, Dr. Cheney has been
engaged in investigating the cardiac function of CFS patients, using
Impedance Cardiography and Doppler Echocardiography. According to his
paper presented at the 2007 IACFS/ME conference, "Chronic Fatigue
Syndrome patients exhibit evidence of diastolic dysfunction at a level
well above that reported for control populations of the same age.
Energy dependent diastolic dysfunction would appear to be a hallmark of
CFS and supports the hypothesis that CFS is a syndrome of cellular
Introducing Dr. Cheney, April 25, 2009:While
our attendees are usually excited to meet and listen to speakers, those
special practitioners who make time for us who share their unique views
about our conditions, there is an extra special buzz in the air tonight.
Our guest is legendary CFS expert, physician and physicist, Paul Cheney.
over twenty years, Dr. Cheney has been a pioneering clinical researcher
in the field of Chronic Fatigue Syndrome (CFS). He has published
numerous articles and lectured around the world on chronic fatigue
Cheney holds a PhD in Physics from Duke University in Durham, NC and is
a graduate (MD) of Emory University School of Medicine in Atlanta, GA
where he also completed his internal medicine residency. He is a board
1990, Dr. Cheney has headed the Cheney Clinic, presently located in
Asheville, NC. The Cheney Clinic specializes in evaluating CFS
patients and has expertise in diagnosis, disability support for and
treatment of chronic fatigue syndrome. No single clinic has drawn as
many CFS patients (currently over 5,000) from as many states (48) and
foreign countries (22) as has the Cheney Clinic.
Tonight’s presentation is entitled
“Chronic Fatigue Syndrome: Is Oxygen the Problem and Why?”
Please welcome Dr. Cheney.
event hostess Elly Brosius
Northern VA CFS/ME, FMS, and OI Support Groups
Chronic Fatigue Syndrome(CFS):
Is Oxygen the Problem and Why?
A Four-part Treatment Protocol
Paul Cheney, MD, PhD
Click photo collage for larger image
Photo Collage by Bob Busby for Ann
Please consider obtaining the slides and / or DVD to see and judge for yourself.
This page and nearly all overviews you encounter are likely to be
just a fraction of the material presented in the 3 hour plus lecture,
and there may be mistakes and/or unintentional misrepresentations.
Not everyone takes the same meanings from a presenters words
or understands it as the presenter intended,
especially when the material is complex and ever evolving.
This overview also includes some "fill in" material from other links,
information from a Cheney patient, a few general definitions and other sources.
Dr. Cheney's 2009 CFS Seminar in Fairfax, VA
four of Dr. Cheney's protocol, which not all patients would require, is
stem cell transfusions. The stems cells used are legal and from
afterbirth or adult sources. The infusions are performed at two clinics outside the USA, mainly to reduce costs for patients. The clinics are owned by an American company which trades on the New York Stock Exchange (NYSE). Two patients recently completed step four and
are already showing improvement in their test results and functioning.
See links below for information about stems cells and clinics.
What was new in this 2009 Seminar?
Why did people travel hundreds of miles to hear it?
CFS: Is Oxygen the Problem and Why?
A Four-Part Treatment Protocol
OverviewIn addition to a broad overview of Chronic Fatigue Syndrome including case definition, clinical
findings, and key medical literature, Dr. Cheney presented on
oxygen toxicity in CFS, evidence of diastolic dysfunction and heart
failure, evidence of an association of CFS with PFO’s (Patent
Foramen Ovales), testing, as well as his current four-part treatment protocol.
Oxygen Toxicity as a Controlling Factor for CFSOne
section of the presentation focused on the research finding of nearly
100% toxicity in CFS patients when oxygen is administered. Dr.
Cheney presented evidence that patients given various treatments were
transformed to an increasingly oxygen tolerant state. The most powerful
treatment protocol was also associated with significant overall
clinical improvement. Dr. Cheney drew conclusions from his data: CFS is
an oxygen toxic state, oxygen toxicity status appears to determine
outcome in therapeutic trials, and oxygen toxicity is key to this
illness.Cell Associated Therapy for Chronic Fatigue Syndrome: Is this the Next Frontier?Dr.
Cheney explained the use of cell signaling factors (CSF's) as therapeutic agents when applied to the skin
using novel transdermal gels. Cell signaling factors are also known as low molecular weight (LMW), mammalian
tissue derived peptides. These cell signaling factors are known to control
gene expression and can shift organ function toward normal.
presented in using these cell signaling factors (CSF's) in chronic fatigue syndrome (CFS) which produced
significant improvement in function. Therapy with CSF's therefore appears to
offer a significant benefit in CFS, especially where it counts the
most, namely, the functioning of the patient.
Ergometry was mentioned again as the best test for convincing the
Social Security Adminstration of disability status. Oxygen plays a key
role in energy production, so exercise physiologists use oxygen
consumption during exercise to tell how much energy a person’s
body is capable of producing. Having people pedal a stationary bicycle
until they can pedal no more tells researchers how much air their lungs
can take in (Ventilation Max) and therefore how much oxygen they use to
produce energy (VO2 Max) at their peak level of effort. Bicycle
Ergometry effectively tells researchers how much energy is being
produced. Besides Dr. Cheney's office, there are places in CAand in NY that do this testing [Article about ergonmetry at Phoenix Rising] and also in TX. Dr. Larry Sharp of Fort Worth, TX, was in attendance and his office also uses this testing.
Cheney uses an echocardiagram machine for hours with patients measuring
how their Isovolumic Relaxation Time (IVRT) changes in response to
various treaments. [Definition: IVRT is the time from aortic valve
mitral valve opening and a noninvasive measure of left ventricular
diastolic function.] Dr. Cheney talks about IVRT as a relating to how
much energy a patient has. His
patient response data to various treatments was presented in detailed
"Echo Terrain Maps," echo as in echocardiograms looking at the IVRT.
TreatmentDr. Cheney and others believe
that phenotypic changes (altered gene expression) must be corrected
before making genotypic changes (changes to the genetic blueprint) such as those made with
the stem cells. What has been putting patients into a low oxygen state vulnerable to the push - crash experience
must first be addressed in steps 1-3.
A redox shift is done with Artesunate. A gut modification program
includes a modified elimination diet, using anti-microbials, repairing
the gut with a colostrum/ glutamine source, and adding in probiotics.
Pretreatment along with Artesunate may include DHEA, Glucose, and Inosine.
Then Cell Signaling Factors (CSF's) are considered, and if needed stem cell infusions.
is in the class of medications known as artemesinins, which
are derivatives from the "quinghaosu" or sweet wormwood plant
(Artemisia annua). It is used often for the treatment of malaria.
Artesunate is available from Hepalin, a California company, their product being called Hepasunate.
Inosine is a compound that is an intermediate in the metabolism of
prescription Nexavir, formerly known as kutapressin, was at one time
used before liver CSF was available because it has some liver cell
signaling factors. [See the Phoenix Rising website and Nexcopharma for more informaiton on Nexavir.]
there are five potent organ cell signaling factors that are used:
heart, brain, pancreas, liver and kidney. The heart factor was the
highlighted as the most effective. These may one day be made available
to the public or through health professionals, currently available it
seems in the U.S.A. only through Dr. Cheney.
Magnesium was praised as very helpful for the heart and one of the audience members was seen using Magnesium sulfate cream
on his carotid artery throughout the evening to keep up with the body's
demands for the mineral. This cream was mentioned on Dr. Cheney's 2006
video. The positive effects from the cream last about an hour.
the sugar in fruit and honey, is still considered something to be
avoided, something that makes CFS worse in Dr. Cheney's view. D-Ribose and vitamin D3
were also not recommended.
Dr. Cheney likens the order of the steps in the treatment protocol to
correcting software or functional problems before putting in a new hard drive.
Corrupt software, or improper functioning, installed on a new hard drive will corrupt the new
system and produce bad results. Stem cells are the last step, a
metaphorical new hard drive if one is needed.
Many patients, especially younger ones and/or those who haven't been ill for years and years,may not need stem cells at all. Dr. Cheney has had several younger patients resume normal function with just the first three steps of his protocol.
If your p450 path is compromised, you become almost an enviromental invalid.
CFS is not a disease. It is an adaptive state. Your body is trying to save your life.
Cheney also discussed some facinating work by a scientist who used urinary
markers to show that when people do recover, they are moved not
back to a normal state of a person who never had illness, but to a new
expression of good health. You cannot go back to what you were, you can
only become a new kind of normal.
- Chronic Fatigue Syndrome -- An Oxygen Toxic Stae
- Echocardiographic Parameter -- IVRT as Energy
- Cell Signaling Factors (CSF's) -- as Therapy
- G = H - TS -- The Energy Guiding Light (G = Gibbs Free Energy)
- The Human Being as a Symbiote (We're only 10% Human!)
- Chronic Fatigue Syndrome as Redox Compensation
For More Information
About stem cells:
From Dr. Cheney:
For the slides from this 2009 talk,
sign up now for the
Cheney Research Newsletter - Anticipated for June 2009.
For more about The Cheney Clinic,
sign up now
The Cheney Clinic Website - Anticipated June 2009
Photos of a few slides from April 2009....
A Sampler of Attendee Comments
mom called 3 times during the event (break times) and i think she got a
lot out of it! THANK YOU SO MUCH FOR ORGANIZING THIS. i know how much
work these things can take.
We need a meeting just to discuss what we heard, to compare what parts we understood.
Does anyone understand what he is saying? Layman's terms, please!
I am more scared now than ever. I'm so afraid for my heart.
what he said is true in part 1 about us all being in heart failure, why
haven't more of us died already? Some of us have been in this group for
15 years, have had symptoms all of our lives. We're still here.
Are the transdermal gels prescription?
He didn't really explain how to use the treatments.
Can we do something with the information he gave us?
I am back home in Ohio safe. I want to thank you for all your
work. It was wonderful that you and your group were able to put
all of it together. Dr. Cheney and his seminar were great and far
better than I expected.
It was very exciting to
see Dr. Cheney in person and be able to hear the results of his latest
medical research and treaments. Dr. Cheney has been one of
the foremost world leaders in CFS research for the past 25
years. It was a wonderful opportunity for us with CFS and
associated illnesses to hear about his findings firsthand. It
really meant lot to me. Thank you.!!!
own story is similar to others with this illness. Over the years,
I read everything I could about CFS. After years of reading and
listening to Dr Cheney's recordings, his explaination of the illness
enabled me to have an understanding of it. Before Dr. Cheney, I
had no idea what was going "wrong" with so many parts of my body and
brain. Once I understood the illness, I could start to try to
Even though Dr Cheney never had me as a patient, I owe most of my improvement to him and his research.
Dr. Cheney has dedicated his life to treating those with CFS and
developing better treatments. He has further developed his
treatments for each patent's functional improvement and cure in some
cases, and has developed a system to measure the progress of his
treatments of each individual. Dr. Cheney's presentation was very
impressive and the positive results for his patients are very
Thank you again,
Blessing to you and everyone in your CFS/FM Group,
We enjoyed the CFS overview last night, it was long but there was some good information near the end.
watched the 2006 DVD about 1000 times. I arrived ready to go to the
next level, to follow as much as possible some more. But now its gone
too far out for me.
A very successful evening - congratulations and thanks!
I am sending in some photos.
am grateful that I was able to make it to the Dr Cheney meeting tonight
even though I forgot to factor in what a sudden arrival of 87 degree
heat does to slow down my get-ready routine. I didn't connect the dots
even though Elly copiously warned us of the anticipated high
temps. I'm also grateful the meeting was a night one so I had a
few extra hours to compensate. I am grateful that I got to meet people
I've emailed with in person tonight at the meeting. It may seem
silly, but it was very exciting to me to get to meet them, and to see
Toni and Elly again. I am grateful for all of the immeasurably
hard work and incredible attention to detail that Elly put into making
this event happen, and to Toni and everyone else that helped to make it
I have to go home and think.
Where do I get the DVD?
Where do I get the DVD?
Where do I get the DVD?
Attendee Comments / Other Related Cheney Seminars discussion elsewhere on the Web
Dr. Cheney Goes His Own Way: the Virginia 2009 Lecture
Bringing the Heat: An ME?CFS Blog by CORT
Thread title: Paul Cheney talk, Fairfax, VA, April 25, 2009
ProHealth ME/CFS & FM Message Board by Attendee Chris
Thread Title: Injectable Magnesium?
ProHealth ME/CFS & FM Message Board 1/30/08
Dr. Cheney presented impressive data to support the successes of
patients able to return to work after even years and years of illness,
he presented little information about those who respond poorly
to his various protocols. CFSupport has group members and recent
contacts who felt their
worsening was not adequately addressed when a patient of the clinic.)
DVD Ordering Information and Support Group Donations
Cheney Seminar 2009 DVD sets available as of June 22, 2009!
DVDs of the Cheney 2009 Seminar are
available for $17 to US addresses and $20 to Canada, including
seminar is on two discs. Two DVDs! To get the whole event, you most
order both of them.... and in the same order so you don't get charged
twice for shipping.
They are identified as
CFS: Is Oxygen the Problem?
CFS: Is Oxygen the Problem? (2).
second one, appears first on the ordering webpage. The NTSC format (US
and Canada, most DVD players around the world) has purple covers and is
at the bottom of the page. The PAL format (Europe, Australia, ...) has
blue covers and appears first on the page.
cost is $6.00 for each disc. The shipping charge for US orders is
$5.00, bringing the cost of the set to $17.00 for US orders.
Canadian and overseas orders will be $6.00 per disc, $8.00 shipping, for a total of $20.
orders into multiple sets, for a support group order for example, and
having them shipped to one address does does reduce shipping costs.
Place your orders through Kunaki.com at:
Cheney Seminar 2009 – Topics Covered
|DISC ONE (1:17)||DISC TWO (1:27)|
case definition; symptom triad;
symptoms vs dynamic dysfunction;
four phases of CFS ;
key scientific literature;
four phases graph;
recovery phase graph;
exercise and oxygen consumption;
lactic acid and anxiety disorders;
magnetic resonance spectroscopy;
difference in FM and CFS on echo;
venous blood gas;
two types of heart failure – systolic vs diastolic;
how to diagnose diastolic dysfunction on echo;
left atrial collapse;
Echo Case / Control Study;
summary of diastolic parameters in CFS;
what to tell a cardiologist;
other echo parameters
* Oxygen & CFS
Everest III study;
IVRT as energy;
* Oxygen Toxicity
PFO’s, migraines, strokes;
oxygen toxicity controls treatment outcomes;
conclusion of concepts;
key enzymes SOD, CAT, GPX;
* Emerging Hypothesis
left shifted on oxyhemoglobin disassociation
pulse oximetry and desaturation;
oxygen metabolism and toxicity
* Four Adaptations to Oxygen Toxicity
HPA axis, cortisol (push/crash);
methylation block (brain, sleep);
microcirculatory left shift (fatigue);
methylation block – neuropsych issues, sleep,
etiology (pathogen, biotoxin, genes, etc)
*Oxygen Toxicity as Control Point
oxygen toxicity generators; energy conundrum;
P450 system; NADPH;
anabolically blocked; superoxide; Environmental Illness (EI); enzymes
CAT, GPx, SOD
*Cell Signaling Factor (CSF) Therapy
heart organ use in history;
messages to stem cells;
*Echo Terrain Maps (ETM)
substances tested on echo (typical results given) - oxygen (neg/bad),
heart CSF (pos/good), porcine liver (neg), adrenal (neg), thymus (neg),
pancreas (pos except in diabetes and insulin resistance), liver + oxygen
(neg); echo terrain maps (ETM’s); ETM’s show response to therapy;
ETM’s of CFS cures;
ETM’s of controls;
testing other treatments on echo –
fructose (neg), glucose (pos), Methyl B-12 plus Folate (neg),
glutathione (neg in most), Provigil (neg), T3 (neg), Vit D3 (neg), CoQ10
(neg in most, but Idebenone always pos); [Methyl B-12 alone (neg)]
* Metabolome / Humans as Symbiotes
gut bacteria as powerful symbiote and influence
*Redox and Artesunate
energy and redox;
viral replication and redox;
Artesunate – “most powerful drug”, shifts redox,
inhibits NF kappaB, antiviral;
Artesunate wipes out oxygen toxicity on echo;
Inosine [Inosine has replaced Imunovir /
*Treatment Protocol & Stem Cells
effectiveness of protocol;
stem cell therapy
[most answers given below have exceptions]
repair a PFO (no);
Rich V.K. and methylation and glutathione;
pancreas CSF, glucose, and diabetes;
CFS and MCS relationship;
use of oxygen in surgery;
supplement NADPH, D-Ribose (no!);
location & contact info for stem cell clinics;
[patient must shift phenotype with CSF’s before receiving stem cells, or new
genetic code from stem cells will eventually be corrupted and illness
The 2-disc DVD set of the April 2009 Cheney Seminar "CFS: Is Oxygen the Problem and Why?" at the Northern VA CFS/FM/OI Support Group in Fairfax, VA, was arranged for by the CFS and FM Support Group of DFW.
Ordering information will also be available at the DFW group website as soon as possible. The information on this NOVA CFS/Fibro/OI Support Group Speaker - Cheney page, is from information posted already to major CFS e-lists and forums by a DFW group representative.
is usually donations that keep support groups doing the work they do in
answering phones and calling people back, arranging for speakers,
handing out copies of articles, etc.
make a general tax-deductible charitable donation to sponsor CFS/FM
Support Group of DFW, use the new PayPal donation icon on their website
homepage or send a check to
make a NON deductible gift to the Northern VA Chronic Fatigue Syndrome,
Fibromyalgia Syndrome, & Orthostatic Intolerance Support Group,
send a check to
Web Links for Paul R. Cheney MD, PhD
Dr. Cheney's sites:
Webpages dedicated to, quoting, mentioning, interviewing Dr. Cheney:
Articles by Paul R Cheney, PhD, MD:
- Oxygen Toxicity as a Locus of Control for Chronic Fatigue Syndrome
- Cell Associated Therapy for Chronic Fatigue Syndrome: Is this the Next Frontier?
- Biochemical evidence for a novel low molecular weight 2-5A-dependent RNase L in chronic fatigue syndrome.
RJ, Peterson DL, O'Brien K, Cheney PR, Herst CV, Reichenbach NL, Kon N,
Horvath SE, Iacono KT, Adelson ME, De Meirleir K, De Becker P,
Charubala R, Pfleiderer W.
J Interferon Cytokine Res. 1997 Jul;17(7):377-85.
- Primary juvenile fibromyalgia syndrome and chronic fatigue syndrome in adolescents.
Bell DS, Bell KM, Cheney PR.
Clin Infect Dis. 1994 Jan;18 Suppl 1:S21-3.
- Cheney PR, Lapp CW: Entero-hepatic resuscitation in patients with chronic fatigue syndrome: A pyramid of nutritional therapy, CFIDS Chronicle, Fall 1993
- Absence of antibody to Mycoplasma fermentans in patients with chronic fatigue syndrome.
Komaroff AL, Bell DS, Cheney PR, Lo SC.
Clin Infect Dis. 1993 Dec;17(6):1074-5. No abstract available.
- A chronic illness characterized by fatigue, neurologic and immunologic disorders, and active human herpesvirus type 6 infection.
Buchwald D, Cheney PR, Peterson DL, Henry B, Wormsley SB, Geiger A, Ablashi DV, Salahuddin SZ, Saxinger C, Biddle R, et al.
Ann Intern Med. 1992 Jan 15;116(2):103-13.
- Retroviral sequences related to human T-lymphotropic virus type II in patients with chronic fatigue immune dysfunction syndrome.
DeFreitas E, Hilliard B, Cheney PR, Bell DS, Kiggundu E, Sankey D, Wroblewska Z, Palladino M, Woodward JP, Koprowski H.
Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2922-6.
- Interleukin-2 and the chronic fatigue syndrome.
Cheney PR, Dorman SE, Bell DS.
Ann Intern Med. 1989 Feb 15;110(4):321. No abstract available.